Multivariate analysis of covariates of adherence among HIV‑positive mothers with low viral suppression

In working to prevent mother‑to‑child transmission of HIV in Northern Uganda, we explored reasons for poor viral load suppression among pregnant and lactating women who were in care and received viral load tests but had not achieved viral suppression. The Ministry of Health in Uganda was interested in understanding the patient factors affecting adherence to treatment to guide the development of tools and interventions to achieve viral suppression for pregnant and lactating women on antiretroviral therapy (ART).

We assessed 122 HIV‑positive mothers with known low viral suppression across 31 health facilities in Northern Uganda using a facility‑based cross‑sectional and mixed methods study design, with retrospective medical record review. Adjusted odds ratios were used to identify the covariates of adherence among HIV positive mothers using logistic regression.

This study identifies common obstacles in adhering to HIV treatment and was part of a larger national evaluation of the performance of integrated care services for mothers. To improve adherence, we recommend use of a screening tool to identify mothers with any of these common challenges so that more intensive adherence support can be provided to these mothers.

Read the full article in AIDS Research and Therapy.

Report Author(s): 
Tamara Nsubuga‑Nyombi, Simon Sensalire, Esther Karamagi, Judith Aloyo, John Byabagambi, Mirwais Rahimzai, Linda Kisaakye Nabitaka and Jacqueline Calnan
Organization(s): 
USAID Applying Science to Strengthen and Improve Systems (ASSIST) Project/URC
ASSIST publication: 
ASSIST publication
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